| Sunday, January 22, 2012 | |||||
| Time | Home | Away | Venue | ||
| 11:30 GMT | Bologna | v | Parma | Stadio Renato Della`Ara | |
| 14:00 GMT | Cagliari | v | Fiorentina | Sant'Elia | |
| 14:00 GMT | Lecce | v | Chievo Verona | ||
| 14:00 GMT | Novara | v | AC Milan | ||
| 14:00 GMT | Palermo | v | Genoa | Renzo Barbera | |
| 14:00 GMT | Siena | v | Napoli | Artemio Franchi | |
| 14:00 GMT | Udinese | v | Catania | Stadio Friuli | |
| 19:45 GMT | Internazionale | v | Lazio | Stadio Giuseppe Meazza | |
| Sunday, January 29, 2012 | |||||
| Time | Home | Away | Venue | ||
| 11:30 GMT | Fiorentina | v | Siena | Stadio Artemio Franchi | |
| 14:00 GMT | AS Roma | v | Bologna | Stadio Olimpico | |
| 14:00 GMT | Cesena | v | Atalanta | Stadio D. Manuzzi | |
| 14:00 GMT | Genoa | v | Napoli | Comunale Luigi Ferraris | |
| 14:00 GMT | Lecce | v | Internazionale | ||
| 14:00 GMT | Palermo | v | Novara | Renzo Barbera | |
| 19:45 GMT | AC Milan | v | Cagliari | Stadio Giuseppe Meazza | |
| 19:45 GMT | Chievo Verona | v | Lazio | Stadio Marc`Antonio Bentegodi | |
| Wednesday, February 1, 2012 | |||||
| Time | Home | Away | Venue | ||
| 17:00 GMT | Atalanta | v | Genoa | Atleti Azzurri d'Italia | |
| 19:45 GMT | Bologna | v | Fiorentina | Stadio Renato Della`Ara | |
| 19:45 GMT | Cagliari | v | AS Roma | Stadio San Elia | |
| 19:45 GMT | Internazionale | v | Palermo | Stadio Giuseppe Meazza | |
| 19:45 GMT | Lazio | v | AC Milan | Stadio Olimpico | |
| 19:45 GMT | Napoli | v | Cesena | Stadio San Paolo | |
| 19:45 GMT | Siena | v | Catania | Artemio Franchi | |
| 19:45 GMT | Udinese | v | Lecce | Stadio Friuli | |
| Thursday, February 2, 2012 | |||||
| Time | Home | Away | Venue | ||
| 19:45 GMT | Novara | v | Chievo Verona | ||
| Sunday, February 5, 2012 | |||||
| Time | Home | Away | Venue | ||
| 14:00 GMT | AC Milan | v | Napoli | Stadio Giuseppe Meazza | |
| 14:00 GMT | AS Roma | v | Internazionale | Stadio Olimpico | |
| 14:00 GMT | Cesena | v | Catania | Stadio D. Manuzzi | |
| 14:00 GMT | Chievo Verona | v | Parma | Stadio Marc`Antonio Bentegodi | |
| 14:00 GMT | Fiorentina | v | Udinese | Stadio Artemio Franchi | |
| 14:00 GMT | Genoa | v | Lazio | Comunale Luigi Ferraris | |
| 14:00 GMT | Juventus | v | Siena | ||
| 14:00 GMT | Lecce | v | Bologna | ||
| 14:00 GMT | Novara | v | Cagliari | ||
| 14:00 GMT | Palermo | v | Atalanta | Renzo Barbera | |
| Sunday, February 12, 2012 | |||||
| Time | Home | Away | Venue | ||
| 14:00 GMT | Atalanta | v | Lecce | Atleti Azzurri d'Italia | |
| 14:00 GMT | Bologna | v | Juventus | Stadio Renato Della`Ara | |
| 14:00 GMT | Cagliari | v | Palermo | Stadio San Elia | |
| 14:00 GMT | Catania | v | Genoa | Stadio Angelo Massimino | |
| 14:00 GMT | Internazionale | v | Novara | Stadio Giuseppe Meazza | |
| 14:00 GMT | Lazio | v | Cesena | Stadio Olimpico | |
| 14:00 GMT | Napoli | v | Chievo Verona | Stadio San Paolo | |
| 14:00 GMT | Parma | v | Fiorentina | Stadio Ennio Tardini | |
| 14:00 GMT | Siena | v | AS Roma | Artemio Franchi | |
| 14:00 GMT | Udinese | v | AC Milan | Stadio Friuli | |
| Saturday, January 21, 2012 | |||||
| Time | Home | Away | Venue | ||
| 12:45 GMT | Norwich City | v | Chelsea | Carrow Road | |
| 15:00 GMT | Everton | v | Blackburn Rovers | Goodison Park | |
| 15:00 GMT | Fulham | v | Newcastle United | Craven Cottage | |
| 15:00 GMT | Queens Park Rangers | v | Wigan Athletic | Loftus Road | |
| 15:00 GMT | Stoke City | v | West Bromwich Albion | Britannia Stadium | |
| 15:00 GMT | Sunderland | v | Swansea City | Stadium of Light | |
| 15:00 GMT | Wolverhampton Wanderers | v | Aston Villa | Molineux Stadium | |
| 17:30 GMT | Bolton Wanderers | v | Liverpool | Reebok Stadium | |
| Sunday, January 22, 2012 | |||||
| Time | Home | Away | Venue | ||
| 13:30 GMT | Manchester City | v | Tottenham Hotspur | Etihad Stadium | |
| 16:00 GMT | Arsenal | v | Manchester United | Emirates Stadium | |
| Tuesday, January 31, 2012 | |||||
| Time | Home | Away | Venue | ||
| 19:45 GMT | Swansea City | v | Chelsea | Liberty Stadium | |
| 19:45 GMT | Tottenham Hotspur | v | Wigan Athletic | White Hart Lane | |
| 19:45 GMT | Wolverhampton Wanderers | v | Liverpool | Molineux Stadium | |
| 20:00 GMT | Everton | v | Manchester City | Goodison Park | |
| 20:00 GMT | Manchester United | v | Stoke City | Old Trafford | |
| Wednesday, February 1, 2012 | |||||
| Time | Home | Away | Venue | ||
| 19:45 GMT | Aston Villa | v | Queens Park Rangers | Villa Park | |
| 20:00 GMT | Blackburn Rovers | v | Newcastle United | Ewood Park | |
| 20:00 GMT | Bolton Wanderers | v | Arsenal | Reebok Stadium | |
| 20:00 GMT | Fulham | v | West Bromwich Albion | Craven Cottage | |
| 20:00 GMT | Sunderland | v | Norwich City | Stadium of Light | |
| Saturday, February 4, 2012 | |||||
| Time | Home | Away | Venue | ||
| 15:00 GMT | Arsenal | v | Blackburn Rovers | Emirates Stadium | |
| 15:00 GMT | Norwich City | v | Bolton Wanderers | Carrow Road | |
| 15:00 GMT | Queens Park Rangers | v | Wolverhampton Wanderers | Loftus Road | |
| 15:00 GMT | Stoke City | v | Sunderland | Britannia Stadium | |
| 15:00 GMT | West Bromwich Albion | v | Swansea City | The Hawthorns | |
| 15:00 GMT | Wigan Athletic | v | Everton | DW Stadium | |
| 17:30 GMT | Manchester City | v | Fulham | Etihad Stadium | |
| Sunday, February 5, 2012 | |||||
| Time | Home | Away | Venue | ||
| 13:30 GMT | Newcastle United | v | Aston Villa | Sports Direct Arena | |
| 16:00 GMT | Chelsea | v | Manchester United | Stamford Bridge | |
| Monday, February 6, 2012 | |||||
| Time | Home | Away | Venue | ||
| 20:00 GMT | Liverpool | v | Tottenham Hotspur | Anfield | |
| Saturday, February 11, 2012 | |||||
| Time | Home | Away | Venue | ||
| 12:45 GMT | Manchester United | v | Liverpool | Old Trafford | |
| 15:00 GMT | Blackburn Rovers | v | Queens Park Rangers | Ewood Park | |
| 15:00 GMT | Bolton Wanderers | v | Wigan Athletic | Reebok Stadium | |
| 15:00 GMT | Everton | v | Chelsea | Goodison Park | |
| 15:00 GMT | Fulham | v | Stoke City | Craven Cottage | |
| 15:00 GMT | Sunderland | v | Arsenal | Stadium of Light | |
| 15:00 GMT | Swansea City | v | Norwich City | Liberty Stadium | |
| 17:30 GMT | Tottenham Hotspur | v | Newcastle United | White Hart Lane | |
| Sunday, February 12, 2012 | |||||
| Time | Home | Away | Venue | ||
| 13:30 GMT | Wolverhampton Wanderers | v | West Bromwich Albion | Molineux Stadium | |
| 16:00 GMT | Aston Villa | v | Manchester City | Villa Park | |
| Saturday, January 21, 2012 | |||||
| Time | Home | Away | Venue | ||
| 17:00 GMT | Espanyol | v | Granada | Cornellà - El Prat | |
| 17:00 GMT | Racing Santander | v | Getafe | Estadio El Sardinero | |
| 19:00 GMT | Real Sociedad | v | Atlético Madrid | Estadio Anoeta | |
| 21:00 GMT | Real Betis | v | Sevilla FC | Estadio Manuel Ruiz de Lopera | |
| Sunday, January 22, 2012 | |||||
| Time | Home | Away | Venue | ||
| 11:00 GMT | Osasuna | v | Valencia | Estadio El Sadar | |
| 15:00 GMT | Rayo Vallecano | v | Mallorca | ||
| 17:00 GMT | Málaga | v | Barcelona | Estadio La Rosaleda | |
| 18:45 GMT | Levante | v | Real Zaragoza | Ciudad de Valencia | |
| 20:30 GMT | Real Madrid | v | Athletic Bilbao | Estadio Santiago Bernabéu | |
| 15:00 GMT | Granada | v | Espanyol | ||
| Monday, January 23, 2012 | |||||
| Time | Home | Away | Venue | ||
| 20:00 GMT | Villarreal | v | Sporting Gijon | Estadio El Madrigal | |
| Saturday, January 28, 2012 | |||||
| Time | Home | Away | Venue | ||
| 17:00 GMT | Espanyol | v | Mallorca | Cornellà - El Prat | |
| 17:00 GMT | Rayo Vallecano | v | Athletic Bilbao | ||
| 19:00 GMT | Real Madrid | v | Real Zaragoza | Estadio Santiago Bernabéu | |
| 21:00 GMT | Villarreal | v | Barcelona | Estadio El Madrigal | |
| Sunday, January 29, 2012 | |||||
| Time | Home | Away | Venue | ||
| 11:00 GMT | Real Betis | v | Granada | Estadio Manuel Ruiz de Lopera | |
| 15:00 GMT | Levante | v | Getafe | Ciudad de Valencia | |
| 15:00 GMT | Real Sociedad | v | Sporting Gijon | Estadio Anoeta | |
| 17:00 GMT | Racing Santander | v | Valencia | Estadio El Sardinero | |
| 20:30 GMT | Málaga | v | Sevilla FC | Estadio La Rosaleda | |
| Monday, January 30, 2012 | |||||
| Time | Home | Away | Venue | ||
| 20:00 GMT | Osasuna | v | Atlético Madrid | Estadio El Sadar | |
| Sunday, February 5, 2012 | |||||
| Time | Home | Away | Venue | ||
| 15:00 GMT | Granada | v | Málaga | ||
| 16:00 GMT | Athletic Bilbao | v | Espanyol | Estadio San Mamés | |
| 16:00 GMT | Atlético Madrid | v | Valencia | Vicente Calderon | |
| 16:00 GMT | Barcelona | v | Real Sociedad | Estadio Camp Nou | |
| 16:00 GMT | Getafe | v | Real Madrid | Coliseum Alfonso Perez | |
| 16:00 GMT | Levante | v | Racing Santander | Ciudad de Valencia | |
| 16:00 GMT | Mallorca | v | Real Betis | Estadio Son Moix | |
| 16:00 GMT | Real Zaragoza | v | Rayo Vallecano | Estadio La Romareda | |
| 16:00 GMT | Sevilla FC | v | Villarreal | Estadio Ramon Sanchez Pizjuan | |
| 16:00 GMT | Sporting Gijon | v | Osasuna | ||
| Sunday, February 12, 2012 | |||||
| Time | Home | Away | Venue | ||
| 15:00 GMT | Villarreal | v | Granada | ||
| 16:00 GMT | Espanyol | v | Real Zaragoza | Cornellà - El Prat | |
| 16:00 GMT | Málaga | v | Mallorca | Estadio La Rosaleda | |
| 16:00 GMT | Osasuna | v | Barcelona | Estadio El Sadar | |
| 16:00 GMT | Racing Santander | v | Atlético Madrid | Estadio El Sardinero | |
| 16:00 GMT | Rayo Vallecano | v | Getafe | ||
| 16:00 GMT | Real Betis | v | Athletic Bilbao | Estadio Manuel Ruiz de Lopera | |
| 16:00 GMT | Real Madrid | v | Levante | Estadio Santiago Bernabéu | |
| 16:00 GMT | Real Sociedad | v | Sevilla FC | Estadio Anoeta | |
| 16:00 GMT | Valencia | v | Sporting Gijon | Estadio Mestalla | |
| Friday, January 20, 2012 | |||||
| Time | Home | Away | Venue | ||
| 19:30 GMT | Borussia Monchengladbach | v | Bayern Munich | Borussia-Park | |
| Saturday, January 21, 2012 | |||||
| Time | Home | Away | Venue | ||
| 14:30 GMT | Nurnberg | v | Hertha Berlin | EasyCredit-Stadion | |
| 14:30 GMT | SC Freiburg | v | FC Augsburg | ||
| 14:30 GMT | Schalke 04 | v | VfB Stuttgart | Veltins-Arena | |
| 14:30 GMT | TSG Hoffenheim | v | Hannover 96 | Rhein-Neckar-Arena | |
| 14:30 GMT | VfL Wolfsburg | v | FC Cologne | Volkswagen Arena | |
| 17:30 GMT | Kaiserslautern | v | Werder Bremen | Fritz-Walter-Stadion | |
| Sunday, January 22, 2012 | |||||
| Time | Home | Away | Venue | ||
| 14:30 GMT | Hamburg SV | v | Borussia Dortmund | HSH Nordbank Arena | |
| 16:30 GMT | Bayer Leverkusen | v | Mainz | BayArena | |
| Friday, January 27, 2012 | |||||
| Time | Home | Away | Venue | ||
| 19:30 GMT | Hannover 96 | v | Nurnberg | AWD-Arena | |
| Saturday, January 28, 2012 | |||||
| Time | Home | Away | Venue | ||
| 14:30 GMT | Bayern Munich | v | VfL Wolfsburg | Allianz Arena | |
| 14:30 GMT | Borussia Dortmund | v | TSG Hoffenheim | Signal-Iduna-Park | |
| 14:30 GMT | FC Augsburg | v | Kaiserslautern | ||
| 14:30 GMT | Hertha Berlin | v | Hamburg SV | Olympiastadion | |
| 14:30 GMT | Werder Bremen | v | Bayer Leverkusen | Weserstadion | |
| 17:30 GMT | FC Cologne | v | Schalke 04 | ||
| Sunday, January 29, 2012 | |||||
| Time | Home | Away | Venue | ||
| 14:30 GMT | Mainz | v | SC Freiburg | ||
| 16:30 GMT | VfB Stuttgart | v | Borussia Monchengladbach | Gottlieb-Daimler-Stadion | |
| Friday, February 3, 2012 | |||||
| Time | Home | Away | Venue | ||
| 19:30 GMT | Nurnberg | v | Borussia Dortmund | EasyCredit-Stadion | |
| Saturday, February 4, 2012 | |||||
| Time | Home | Away | Venue | ||
| 14:30 GMT | Bayer Leverkusen | v | VfB Stuttgart | BayArena | |
| 14:30 GMT | Hertha Berlin | v | Hannover 96 | Olympiastadion | |
| 14:30 GMT | Schalke 04 | v | Mainz | Veltins-Arena | |
| 14:30 GMT | TSG Hoffenheim | v | FC Augsburg | Rhein-Neckar-Arena | |
| 14:30 GMT | VfL Wolfsburg | v | Borussia Monchengladbach | Volkswagen Arena | |
| 17:30 GMT | Hamburg SV | v | Bayern Munich | HSH Nordbank Arena | |
| Sunday, February 5, 2012 | |||||
| Time | Home | Away | Venue | ||
| 14:30 GMT | SC Freiburg | v | Werder Bremen | ||
| 16:30 GMT | Kaiserslautern | v | FC Cologne | Fritz-Walter-Stadion | |
| Friday, February 10, 2012 | |||||
| Time | Home | Away | Venue | ||
| 19:30 GMT | VfL Wolfsburg | v | SC Freiburg | Volkswagen Arena | |
| Saturday, February 11, 2012 | |||||
| Time | Home | Away | Venue | ||
| 14:30 GMT | Bayern Munich | v | Kaiserslautern | Allianz Arena | |
| 14:30 GMT | Borussia Dortmund | v | Bayer Leverkusen | Signal-Iduna-Park | |
| 14:30 GMT | Mainz | v | Hannover 96 | ||
| 14:30 GMT | VfB Stuttgart | v | Hertha Berlin | Gottlieb-Daimler-Stadion | |
| 14:30 GMT | Werder Bremen | v | TSG Hoffenheim | Weserstadion | |
| 17:30 GMT | Borussia Monchengladbach | v | Schalke 04 | Borussia Park | |
| Sunday, February 12, 2012 | |||||
| Time | Home | Away | Venue | ||
| 14:30 GMT | FC Augsburg | v | Nurnberg | impuls arena | |
| 16:30 GMT | FC Cologne | v | Hamburg SV | Rhein Energie Stadion | |
| Friday, February 17, 2012 | |||||
| Time | Home | Away | Venue | ||
| 19:30 GMT | TSG Hoffenheim | v | Mainz | Rhein-Neckar-Arena | |
| Tuesday, February 14, 2012 | |||||
| Time | Home | Away | Stage | Venue | |
| 19:45 GMT | Bayer Leverkusen | v | Barcelona | Round of 16 | BayArena |
| 19:45 GMT | Lyon | v | Apoel Nicosia | Round of 16 | Stade de Gerland |
| Tuesday, February 21, 2012 | |||||
| Time | Home | Away | Stage | Venue | |
| 17:00 GMT | CSKA Moscow | v | Real Madrid | Round of 16 | Luzhniki Stadium |
| 19:45 GMT | Napoli | v | Chelsea | Round of 16 | San Paolo |
| Wednesday, February 22, 2012 | |||||
| Time | Home | Away | Stage | Venue | |
| 19:45 GMT | FC Basel | v | Bayern Munich | Round of 16 | St Jakob-Park |
| 19:45 GMT | Marseille | v | Internazionale | Round of 16 | Stade Vélodrome |
| Wednesday, March 7, 2012 | |||||
| Time | Home | Away | Stage | Venue | |
| 19:45 GMT | Apoel Nicosia | v | Lyon | Round of 16 | Neo GSP Stadium |
| 19:45 GMT | Barcelona | v | Bayer Leverkusen | Round of 16 | Camp Nou |
| Tuesday, March 13, 2012 | |||||
| Time | Home | Away | Stage | Venue | |
| 19:45 GMT | Bayern Munich | v | FC Basel | Round of 16 | Allianz Arena |
| 19:45 GMT | Internazionale | v | Marseille | Round of 16 | Giuseppe Meazza |